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PLOS BiologyDoes neuronal information storage involve nanoscopic structural changes at <a href="https://fediscience.org/tags/synapses" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#synapses</a>? @olenas_kim &co use nanophysiology & functional EM to reveal structural changes of <a href="https://fediscience.org/tags/hippocampal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hippocampal</a> <a href="https://fediscience.org/tags/ActiveZones" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ActiveZones</a> during chemical potentiation @ISTAustria <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/3V22v7h" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/3V22v7h</a>

PLOS BiologyModeling the <a href="https://fediscience.org/tags/hippocampus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hippocampus</a>: @BlueBrainPjt presents a community-based, full-scale in silico model of the rat <a href="https://fediscience.org/tags/hippocampal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hippocampal</a> CA1 region that integrates diverse experimental data from synapse to network <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/3ApZgzz" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/3ApZgzz</a>

kari hoffmanI find this article by Ferro just out in nature communication <a href="https://rdcu.be/dOzT2" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://rdcu.be/dOzT2</a> is an interesting intersection between value-based decision-making, embodied cognition/active vision, and memory <a href="https://neuromatch.social/tags/reactivation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#reactivation</a> or <a href="https://neuromatch.social/tags/reinstatement" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#reinstatement</a>. Looking is doing some heavy lifting. And lookie there, I didn't even mention the <a href="https://neuromatch.social/tags/orbitofrontalcortex" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#orbitofrontalcortex</a> recordings they did! It caught my eye (sorry) b/c some of the scanpath analysis our lab's done in the past suggests that prior to looking at a remembered, rewarded visual target, there's an uptick in <a href="https://neuromatch.social/tags/hippocampal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hippocampal</a> <a href="https://neuromatch.social/tags/ripples" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ripples</a> (Leonard et al., Current Biol 2017), which are thought to signal the underlying reactivation of task-relevant activity patterns. And of course, there's work by a number of groups on memory guidance to rewarding/goal targets, that rely on hippocampal function. Ours based on an MTL amnesic: Yoo, et al., (2020). Long-term memory and hippocampal function support predictive gaze control during goal-directed search. Journal of Vision, <a href="https://doi.org/10.1167/jov.20.5.10" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://doi.org/10.1167/jov.20.5.10</a> following from Chau et al., 2011, and the changes in scanpaths and pupil responses of aging adults and people with Alzheimer's disease, too: Dragan, M. C.,et al., (2017). Behavioural Brain Research, <a href="https://doi.org/10.1016/j.bbr.2016.09.014" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://doi.org/10.1016/j.bbr.2016.09.014</a> Where we choose to look says so much: see e.g. Kragel/Voss; Castelhano/Henderson, Wynn/Buchsbaum/Olsen/Ryan esp what Jordana Wynn followed up with on the scanpath reinstatements suggests a really intertwined relationship between memory, eye movements, and learning/decisions about goals. (forgive that I'm missing many others and pls add below!)TL;DR The foraging decision-making folks and the memory-guided vision folks need to be increasingly up in each other's business. Here's that Ferro link: <a href="https://rdcu.be/dOzT2" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://rdcu.be/dOzT2</a><a href="https://a.gup.pe/u/cogneurophys" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@cogneurophys</a>

Norobiik @Norobiik@noc.socialThey found that each rat <a href="https://noc.social/tags/Hippocampal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Hippocampal</a> synapse can store between 4.1 and 4.6 bits of <a href="https://noc.social/tags/information" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#information</a>.This means the <a href="https://noc.social/tags/HumanBrain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HumanBrain</a> may be capable of holding at least a <a href="https://noc.social/tags/petabyte" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#petabyte</a> of information, equivalent to the data contained on the entire <a href="https://noc.social/tags/Internet" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Internet</a> Human brain can hold 10 times more information than previously thought, scientists say <a href="https://www.msn.com/en-gb/health/other/human-brain-can-hold-10-times-more-information-than-previously-thought-scientists-say/ar-BB1nO76H?ocid=emmx-mmx-feeds&PC=EMMX01" rel="nofollow noopener noreferrer" target="_blank">https://www.msn.com/en-gb/health/other/human-brain-can-hold-10-times-more-information-than-previously-thought-scientists-say/ar-BB1nO76H?ocid=emmx-mmx-feeds&PC=EMMX01</a>

Lynn NadelI'm posting something about memory that I find intriguing - many of you might also find it interesting. The title is "Subjective Experience is a brand new Episodic Memory", and the link is <a href="https://youtu.be/kBDelfotYvE" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://youtu.be/kBDelfotYvE</a>Have a look.<a href="https://neuromatch.social/tags/hippocampus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hippocampus</a> <a href="https://neuromatch.social/tags/hippocampusgurus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hippocampusgurus</a> <a href="https://neuromatch.social/tags/hippocampal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hippocampal</a>

PLOS Biology<a href="https://fediscience.org/tags/CrossFrequencyCoupling" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CrossFrequencyCoupling</a> (CFC) in cortico-<a href="https://fediscience.org/tags/hippocampal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hippocampal</a> networks enables maintenance of multiple visuo-spatial items in <a href="https://fediscience.org/tags/WorkingMemory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#WorkingMemory</a>. This study shows it also extends to <a href="https://fediscience.org/tags/auditory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#auditory</a> info, suggesting CFC as a global mechanism for information processing in the human brain <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/3uXjhe6" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/3uXjhe6</a>

El Duvelle Neuro<a href="https://mastodon.social/@thetransmitter" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@thetransmitter</a> Oh yes - like this (<a href="https://neuromatch.social/tags/Hippocampal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Hippocampal</a> <a href="https://neuromatch.social/tags/ThetaSequences" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ThetaSequences</a>): <a href="https://m.youtube.com/watch?v=IU8wKl5PcLU" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://m.youtube.com/watch?v=IU8wKl5PcLU</a>Or this (<a href="https://neuromatch.social/tags/HippocampalReplay" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HippocampalReplay</a>): <a href="https://m.youtube.com/watch?v=q0kD2RSejRo" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://m.youtube.com/watch?v=q0kD2RSejRo</a>(source: <a href="https://neuromatch.social/tags/vanDerMeerLab" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#vanDerMeerLab</a>)

Fabrizio MusacchioFresh new work by Sučević and Schapiro (2023) on A <a href="https://sigmoid.social/tags/NeuralNetwork" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NeuralNetwork</a> model of <a href="https://sigmoid.social/tags/hippocampal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hippocampal</a> contributions to category <a href="https://sigmoid.social/tags/learning" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#learning</a>🌍 <a href="https://doi.org/10.7554/eLife.77185" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://doi.org/10.7554/eLife.77185</a><a href="https://sigmoid.social/tags/CompNeuro" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CompNeuro</a> <a href="https://sigmoid.social/tags/Neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Neuroscience</a> <a href="https://sigmoid.social/tags/modelling" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#modelling</a> <a href="https://fediscience.org/@ekmiller/111569339907921238" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://fediscience.org/@ekmiller/111569339907921238</a>

Fabrizio Musacchio"<a href="https://sigmoid.social/tags/Hippocampal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Hippocampal</a> neurons reinstate specific episodic memories in humans. These <a href="https://sigmoid.social/tags/EpisodeSpecificNeurons" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#EpisodeSpecificNeurons</a> are independent of <a href="https://sigmoid.social/tags/ConceptNeurons" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ConceptNeurons</a> or <a href="https://sigmoid.social/tags/TimeCells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TimeCells</a> and code the conjunction of elements that make up the event." according to Luca D. Kolibius (1st author, <a href="https://twitter.com/LucaKolibius/status/1709953380779499696" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://twitter.com/LucaKolibius/status/1709953380779499696</a>)

Fabrizio MusacchioThere will be a talk by Peter Jonas (ISTAustria) on "<a href="https://sigmoid.social/tags/Synaptic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Synaptic</a> mechanisms of <a href="https://sigmoid.social/tags/patterncompletion" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#patterncompletion</a> in the <a href="https://sigmoid.social/tags/hippocampal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hippocampal</a> <a href="https://sigmoid.social/tags/CA3" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CA3</a> region":⏰ Thu July 27 at 4.15pm CEST 🌎 <a href="https://t.co/tlk4CorzwE" rel="nofollow noopener noreferrer" target="_blank">https://t.co/tlk4CorzwE</a> 📍 University of <a href="https://sigmoid.social/tags/T%C3%BCbingen" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Tübingen</a>, Hertie-Institut für klinische Hirnforschung (HIH), Host: Ulrike Hedrich<a href="https://sigmoid.social/tags/neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuroscience</a>

Fabrizio MusacchioRethinking the <a href="https://sigmoid.social/tags/hippocampal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hippocampal</a> <a href="https://sigmoid.social/tags/cognitivemap" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cognitivemap</a> as a <a href="https://sigmoid.social/tags/metalearning" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#metalearning</a> computational module – New publication by Luca Ambrogioni & H. Freyja Ólafsdóttir (2023)📔 <a href="https://doi.org/10.1016/j.tics.2023.05.011" rel="nofollow noopener noreferrer" target="_blank">https://doi.org/10.1016/j.tics.2023.05.011</a><a href="https://sigmoid.social/tags/computationalneuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#computationalneuroscience</a> <a href="https://sigmoid.social/tags/learning" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#learning</a>

PLOS BiologyNew insights into how hippocampal <a href="https://fediscience.org/tags/MemoryFormation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MemoryFormation</a> & recall is controlled by a disinhibition-based mechanism, supported by <a href="https://fediscience.org/tags/hippocampal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hippocampal</a> <a href="https://fediscience.org/tags/somatostatin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#somatostatin</a> interneurons & their pontine <a href="https://fediscience.org/tags/brainstem" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#brainstem</a> inputs from the <a href="https://fediscience.org/tags/NucleusIncertus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NucleusIncertus</a> <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/3NkleaD" rel="nofollow noopener noreferrer" target="_blank">https://plos.io/3NkleaD</a>

PLOS Biology<a href="https://fediscience.org/tags/ephys" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ephys</a> study of monkeys reveals a 2-stage mechanism for recalling <a href="https://fediscience.org/tags/SemanticMemory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SemanticMemory</a>: 1. retrieve its allocentric representation in <a href="https://fediscience.org/tags/PerirhinalCortex" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PerirhinalCortex</a>, 2. represent the retrieved information in the 1st-person perspective by <a href="https://fediscience.org/tags/hippocampal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hippocampal</a> neurons <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/3qB4Olx" rel="nofollow noopener noreferrer" target="_blank">https://plos.io/3qB4Olx</a>

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